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KMID : 1155520170120020169
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Anesthesia and Pain Medicine
2017 Volume.12 No. 2 p.169 ~ p.175
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Perioperative gabapentin as a component of multimodal analgesia for postoperative pain after total knee arthroplasty
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Khuvtsagaan Bayalagmaa
Lundeg Ganbold
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Abstract
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Background: Total knee arthroplasty (TKA) causes considerable postoperative pain. This study investigated the analgesic effects of gabapentin on postoperative pain in patients undergoing unilateral TKA in Mongolia.
Methods: The study randomly assigned 95 patients with American Society of Anesthesiologists physical status class 1?3 scheduled for unilateral TKA into two groups. The treatment group (n = 49) was given gabapentin 600 mg 2 h preoperatively and gabapentin 300 mg in the evening for 3 days postoperatively. The control group (n = 46) was given identical looking placebo capsules. Pain using a visual analogue scale (VAS) and postoperative nausea and vomiting were assessed every hour postoperatively for 6 h and then every 3 h for the next 72 h. The total consumption of fentanyl in both groups was recorded at 24 and 48 h postoperatively.
Results: The very low VAS scores in both groups did not differ significantly. Patients in the treatment group used less fentanyl on the second day (P = 0.001). The incidence of nausea and vomiting were similar in both groups, except for the low incidence of nausea in the treatment group in the first 6 h postoperatively.
Conclusions: Perioperative gabapentin may be a component of a multimodal analgesia method because it reduced fentanyl consumption in patients who underwent TKA. However, the overall low VAS scores do not allow any firm conclusions.
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KEYWORD
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Gabapentin, Knee arthroplasty, Postoperative pain
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